Interrelation between the parameters of endogenous vascular regulation, oxidative stress and the markers of inflammatory response in COVID-19 patients while on extracorporeal membrane oxygenation

Introduction. Extracorporeal membrane oxygenation has found wide application in clinical practice during the COVID-19 pandemic. Oxidative stress, endothelial dysfunction, and systemic inflammatory response syndrome play an important role pathogenesis of COVID-19. Our research was designed to study correlations in-between those factors impact extracorporeal on them. Aim. The function patients with oxygenation. Material methods. In course a prospective study, we examined 100 aged 26 75 years, median 55 years [47;60], who were treated at N.V. Sklifosovsky Research Institute for Emergency Medicine, using As control group (normal), 25 practically healthy people whose age 32 [25;39] examined. vascular endothelium assessed by content nitric oxide stable metabolites blood serum level angiotensin-converting enzyme. Next, ratio metabolite enzyme calculated, reflecting imbalance between endotheliumdependent vasodilation vasoconstriction. To assess severity oxidative stress serum, malondialdehyde determined as marker lipid peroxidation. state antioxidant system terms total status serum. presence peroxidation judged coefficient, i.e. activity. Results. analysis showed progression impaired regulation, activation free radical processes, prooxidant/antioxidant system, well process decrease markers severity. Conclusion. Further studies correlation damage may be fundamental importance explaining pathophysiological mechanisms developing new treatments such patients.